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Pentapharm是一家历史可追溯至1948年，位于瑞士高科技生物制品高科技公司，致力于为制药、诊断及化妆品研究与应用领域提供可靠的活性原料成分及系统的解决方案。凭借对市场的快速响应及的研发管理机制，Pentapharm把握住了世界制药、诊断试剂及化妆品工业的发展趋势，开发出了精细的研发设备和工艺，以及有利于环境保护的生产工艺与设备。同时，通过与战略合作伙伴DSM 营养产品公司 (总部位于瑞士的 Kaiseraugst)，Pentapharm能为您提供更多的生物活性产品。Pentapharm供应的产品包括凝血、制药、化妆品活性成分等相关产品，并提供定制化的项目研究、工业化生产服务。
Batroxobin
Description: | Batroxobin is a thrombin-like proteolytic enzyme isolated from the venom of Bothrops | ||
| atrox. It splits the 16 Arg-17 Gly bond in the Aa-chain of fibrinogen and causes the | ||
| release of fibrinopeptide A and the formation of fibrin I monomer or Des-AA-monomer | ||
| which spontaneously aggregates into a clot of fibrin I. | ||
| Batroxobin also induces the release of tPA from endothelium. | ||
Application: | Due to its specific action on fibrinogen and its ability to clot plaet-rich plasma without | ||
| affecting the integrity and functions of the plaets, and thanks to its insensitivity to | ||
| thrombin inhibitors, batroxobin has found several applications as a tool in blood | ||
| coagulation research and diagnosis. | ||
| Batroxobin can be used to determine fibrinogen in plasma, to measure the batroxobin | ||
| clotting time (Reptilase time) as a heparin-insensitive parallel to the thrombin time, to | ||
| investigate dysfibrinogenemia, and to test the contractile system of plaets. | ||
Origin: | Bothrops atrox snake venom | ||
MW: | approx. 43’000 |
| |
Storage: | May be used by the expiry date given on the label when stored unopened, protected | ||
| from moisture. Avoid contamination of the reagents by micro-organisms. | ||
| Shipment of product does not require cooling during the time of transportation. | ||
| Vial | 100 BU/vial | 2°–8°C |
| Bulk | 100 BU/mg | -20°C |
References: | Stocker K. |
| |
| Application of snake venom proteins in the diagnosis of hemostatic disorders. | ||
| In: Medical Use of Snake Venom Proteins, Stocker K, ed. Boca Raton: CRC-Press | ||
| 1990; 213-52. |
| |
Package size: Vial containing 100 BU | Code: | 101-04 | |
| Bulk [100 BU/mg] |
| 101-02 |
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